The lateral habenula is not required for ethanol dependence-induced escalation of drinking

  • Koob GF, Volkow ND. Neurocircuitry of addiction. Neuropsychopharmacology. 2010;35:217–38.

    PubMed Google Scholar

  • Gilpin NW, et al. Operant behavior and alcohol levels in blood and brain of alcohol-dependent rats. Alcohol Clin Exp Res. 2009;33:2113–23.

    CAS PubMed PubMed Central Google Scholar

  • Vendruscolo LF, Roberts AJ. Operant alcohol self-administration in dependent rats: Focus on the vapor model. Alcohol. 2014;48:277–86.

    CAS PubMed Google Scholar

  • O’Dell LE, Roberts AJ, Smith RT, Koob GF. Enhanced alcohol self-administration after intermittent versus continuous alcohol vapor exposure. Alcohol Clin Exp Res. 2004;28:1676–82.

    PubMed Google Scholar

  • Rassnick S, Heinrichs SC, Britton KT, Koob GF. Microinjection of a corticotropin-releasing factor antagonist into the central nucleus of the amygdala reverses anxiogenic-like effects of ethanol withdrawal. Brain Res. 1993;605:25–32.

    CAS PubMed Google Scholar

  • Roberts AJ, Cole M, Koob GF. Intra-amygdala muscimol decreases operant ethanol self-administration in dependent rats. Alcohol Clin Exp Res. 1996;20:1289–98.

    CAS PubMed Google Scholar

  • de Guglielmo G, et al. Inactivation of a CRF-dependent amygdalofugal pathway reverses addiction-like behaviors in alcohol-dependent rats. Nat Commun. 2019;10:1238.

    PubMed PubMed Central Google Scholar

  • Cunningham CL, Fidler TL, Murphy KV, Mulgrew JA, Smitasin PJ. Time-dependent negative reinforcement of ethanol intake by alleviation of acute withdrawal. Biol Psychiatry. 2013;73:249–55.

    CAS PubMed Google Scholar

  • Aizawa H, Kobayashi M, Tanaka S, Fukai T, Okamoto H. Molecular characterization of the subnuclei in rat habenula. J Comp Neurol. 2012;520:4051–66.

    CAS PubMed Google Scholar

  • Nambodiri VMK, Rodriguez-Romaguera J, Stuber GD. The habenula. Curr Biol. 2016;26:R873–77.

    CAS PubMed Google Scholar

  • Zahm DS, Root DH. Review of the cytology and connections of the lateral habenula, an avatar of adaptive behaving. Pharmacol Biochem Behav. 2017;162:3–21.

    CAS PubMed PubMed Central Google Scholar

  • Brinschwitz K, et al. Glutamatergic axons from the lateral habenula mainly terminate on GABAergic neurons of the ventral midbrain. Neuroscience. 2010;168:463–76.

    CAS PubMed Google Scholar

  • Hu H, Cui Y, Yang Y. Circuits and functions of the lateral habenula in health and in disease. Nat Rev Neurosci. 2020;21:277–95.

    CAS PubMed Google Scholar

  • Quina LA, et al. Efferent pathways of the mouse lateral habenula: efferent pathways of the mouse lateral habenula. J Comp Neurol. 2015;523:32–60.

    PubMed Google Scholar

  • Zhou L, et al. Organization of functional long-range circuits controlling the activity of serotonergic neurons in the dorsal raphe nucleus. Cell Rep. 2017;18:3018–32.

    CAS PubMed Google Scholar

  • Matsumoto M, Hikosaka O. Lateral habenula as a source of negative reward signals in dopamine neurons. Nature. 2007;447:1111–5.

    CAS PubMed Google Scholar

  • Matsumoto M, Hikosaka O. Representation of negative motivational value in the primate lateral habenula. Nat Neurosci. 2009;12:77–84.

    CAS PubMed Google Scholar

  • Hong S, Jhou TC, Smith M, Saleem KS, Hikosaka O. Negative reward signals from the lateral habenula to dopamine neurons are mediated by rostromedal tegmental nucleus in primates. J Neurosci. 2011;31:11457–71.

    CAS PubMed PubMed Central Google Scholar

  • Laurent V, Wong FL, Balleine BW. The lateral habenula and its input to the rostromedial tegmental nucleus mediates outcome-specific conditioned inhibition. J Neurosci. 2017;37:10932–42.

    CAS PubMed PubMed Central Google Scholar

  • Li H, et al. Three rostromedial tegmental afferents drive triply dissociable aspects of punishment learning and aversive valence encoding. Neuron. 2019;104:987–99.e4

    CAS PubMed PubMed Central Google Scholar

  • Proulx CD, et al. A neural pathway controlling motivation to exert effort. Proc Natl Acad Sci. 2018;115:5792–7.

    CAS PubMed PubMed Central Google Scholar

  • Stamatakis AM, Stuber GD. Activation of lateral habenula inputs to the ventral midbrain promotes behavioral avoidance. Nat Neurosci. 2012;15:1105–7.

    CAS PubMed PubMed Central Google Scholar

  • Coffey KR, Marx RG, Vo EK, Nair SG, Neumaier JF. Chemogenetic inhibition of lateral habenula projections to the dorsal raphe nucleus reduces passive coping and perseverative reward-seeking in rats. Neuropsychopharmacology. 2020;45:1115–24.

    CAS PubMed PubMed Central Google Scholar

  • Lammel S, et al. Input-specific control of reward and aversion in the ventral tegmental area. Nature. 2012;491:212–7.

    CAS PubMed PubMed Central Google Scholar

  • Li B, et al. Synaptic potentiation onto habenula neurons in the learned helplessness model of depression. Nature. 2011;470:535–9.

    CAS PubMed PubMed Central Google Scholar

  • Szőnyi A, et al. Median raphe controls acquisition of negative experience in the mouse. Science. 2019;366:eaay8746.

    PubMed Google Scholar

  • Clerke JA, Congiu M, Mameli M. Neuronal adaptations in the lateral habenula during drug withdrawal: Preclinical evidence for addiction therapy. Neuropharmacology. 2021;192:108617.

    CAS PubMed Google Scholar

  • Mathis V, Kenny PJ. From controlled to compulsive drug-taking: The role of the habenula in addiction. Neurosci Biobehav Rev. 2019;106:102–11.

    PubMed Google Scholar

  • Shah A, et al. The lateral habenula and alcohol: Role of glutamate and M-type potassium channels. Pharmacol Biochem Behav. 2017;162:94–102.

    CAS PubMed Google Scholar

  • Valentinova K, et al. Morphine withdrawal recruits lateral habenula cytokine signaling to reduce synaptic excitation and sociability. Nat Neurosci. 2019;22:1053–6.

    CAS PubMed Google Scholar

  • Haack AK, et al. Lesions of the lateral habenula increase voluntary ethanol consumption and operant self-administration, block yohimbine-induced reinstatement of ethanol seeking, and attenuate ethanol-induced conditioned taste aversion. PLoS ONE. 2014;9:e92701.

    PubMed PubMed Central Google Scholar

  • Glover EJ, McDougle MJ, Siegel GS, Jhou TC, Chandler LJ. Role for the rostromedial tegmental nucleus in signaling the aversive properties of alcohol. Alcohol Clin Exp Res. 2016;40:1651–61.

    CAS PubMed PubMed Central Google Scholar

  • Tandon S, Keefe KA, Taha SA. Excitation of lateral habenula neurons as a neural mechanism underlying ethanol-induced conditioned taste aversion: LHb activity mediates ethanol-induced aversion. J Physiol. 2017;595:1393–412.

    CAS PubMed Google Scholar

  • Zuo W, et al. Ethanol drives aversive conditioning through dopamine 1 receptor and glutamate receptor-mediated activation of lateral habenula neurons: LHb and alcohol addiction. Addict Biol. 2017;22:103–16.

    CAS PubMed Google Scholar

  • Sheth C, Furlong TM, Keefe KA, Taha SA. The lateral hypothalamus to lateral habenula projection, but not the ventral pallidum to lateral habenula projection, regulates voluntary ethanol consumption. Behav Brain Res. 2017;328:195–208.

    CAS PubMed PubMed Central Google Scholar

  • Kang S, et al. Ethanol withdrawal drives anxiety-related behaviors by reducing m-type potassium channel activity in the lateral habenula. Neuropsychopharmacology. 2017;42:1813–24.

    CAS PubMed PubMed Central Google Scholar

  • Kang S, Li J, Bekker A, Ye JH. Rescue of glutamate transport in the lateral habenula alleviates depression- and anxiety-like behaviors in ethanol-withdrawn rats. Neuropharmacology. 2018;129:47–56.

    CAS PubMed Google Scholar

  • Li J, et al. Inhibition of AMPA receptor and CaMKII activity in the lateral habenula reduces depressive-like behavior and alcohol intake in rats. Neuropharmacology. 2017;126:108–20.

    CAS PubMed PubMed Central Google Scholar

  • Zuo W, et al. Ethanol potentiates both GABAergic and glutamatergic signaling in the lateral habenula. Neuropharmacology. 2017;113:178–87.

    CAS PubMed Google Scholar

  • Shiwalkar, N, Zuo, W, Bekker A, Ye JH, The role of the lateral habenula circuitries in alcohol use disorders. In Neuroscience of Alcohol 153-61 (Elsevier, 2019). https://doi.org/10.1016/B978-0-12-813125-1.00016-7.

  • Glover EJ, Starr EM, Chao Y, Jhou TC, Chandler LJ. Inhibition of the rostromedial tegmental nucleus reverses alcohol withdrawal-induced anxiety-like behavior. Neuropsychopharmacology (2019). https://doi.org/10.1038/s41386-019-0406-8.

  • Smith RJ, Anderson RI, Haun HL, Mulholland PJ, Griffin WC 3rd, Lopez MF, et al. Dynamic c-Fos changes in mouse brain during acute and protracted withdrawal from chronic intermittent ethanol exposure and relapse drinking. Addict. Biol. 2020;25:e12804. https://doi.org/10.1111/adb.12804.

    CAS Article PubMed Google Scholar

  • Brown PL, Shepard PD. Lesions of the fasciculus retroflexus alter footshock-induced cfos expression in the mesopontine rostromedial tegmental area of ​​rats. PLoS ONE. 2013;8:e60678.

    CAS PubMed PubMed Central Google Scholar

  • Jhou TC, et al. Cocaine drives aversive conditioning via delayed activation of dopamine-responsive habenular and midbrain pathways. J Neurosci. 2013;33:7501–12.

    CAS PubMed PubMed Central Google Scholar

  • Meye FJ, et al. Shifted pallidal co-release of GABA and glutamate in habenula drives cocaine withdrawal and relapse. Nat Neurosci. 2016;19:1019–24.

    CAS PubMed Google Scholar

  • Lahti L, et al. Differentiation and molecular heterogeneity of inhibitory and excitatory neurons associated with midbrain dopaminergic nuclei. Development. 129957 (2015). https://doi.org/10.1242/dev.129957.

  • Smith RJ, Vento PJ, Chao YS, Good CH, Jhou TC. Gene expression and neurochemical characterization of the rostromedal tegmental nucleus (RMTg) in rats and mice. Brain Structure Function. 2019;224:219–38.

    CAS PubMed Google Scholar

  • Jhou TC, Fields HL, Baxter MG, Saper CB, Holland PC. The Rostromedial Tegmental Nucleus (RMTg), a GABAergic afferent to midbrain dopamine neurons, encodes aversive stimuli and inhibits motor responses. Neuron. 2009;61:786–800.

    CAS PubMed PubMed Central Google Scholar

  • Leave a Comment